In 1963 vaccine scientist Maurice Hilleman cultured mumps virus from the throat of his own sick five-year-old daughter, Jeryl Lynn, and built a vaccine that still bears her name and nearly erased a leading cause of childhood deafness. The humbling lesson came later, when mumps surged back among young adults who had received both doses, showing that immunity fades. The CDC's advisers recommended a third dose for people at high risk during outbreaks.
The evidence points to waning immunity rather than vaccine failure or a mutating virus. The third dose is recommended only for people at increased risk during an outbreak, and mumps was never declared eliminated in the U.S.