Typhoid was the price American cities paid for drinking their own sewage, and it was conquered by sand filters, chlorine, and a federal standard rather than a drug. Mary Mallon, identified in 1907 as the first healthy carrier in North America, became its human face and was detained for most of her life. The Public Health Service's decisive contribution was the first federal drinking-water standards in 1914.
Scholars still weigh whether Mallon was treated justly, as she was singled out and held longer than other carriers yet also endangered others. The estimate that clean water drove about half the urban death-rate decline is influential but approximate, and the 1914 standard legally covered only interstate carriers at first.